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- Title
Interphase FISH on TEL/AML1 positive acute lymphoblastic leukemia relapses--analysis of clinical relevance of additional TEL and AML1 copy number changes.
- Authors
Peter, Anita; Heiden, Thomas; Taube, Tillmann; Körner, Gabriele; Seeger, Karl
- Abstract
TEL/AML1 (ETV6/RUNX1) fusion resulting from the translocation t(12;21)(p13;q22) constitutes the most common chimeric fusion gene in initial childhood B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) (19-27%) and has been associated with good prognosis. Three secondary aberrations in TEL/AML1 positive ALL have been suspected to negatively influence outcome: deletion of the second TEL allele (T), gain of the second AML1 allele (A) and duplication of the derivative chromosome 21 (der(21), TA). Many studies have explored such aberrations in initial disease, while only few reports have investigated them in relapses.
- Publication
European journal of haematology, 2009, Vol 83, Issue 5, p420
- ISSN
1600-0609
- Publication type
Journal Article
- DOI
10.1111/j.1600-0609.2009.01315.x