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- Title
Cytogenetic studies at diagnosis in polycythemia vera: clinical and JAK2V617F allele burden correlates.
- Authors
Gangat, Naseema; Strand, Jacob; Lasho, Terra L; Finke, Christy M; Knudson, Ryan A; Pardanani, Animesh; Li, Chin-Yang; Ketterling, Rhett P; Tefferi, Ayalew
- Abstract
The prognostic significance of cytogenetic findings at diagnosis in polycythemia vera (PV) was investigated in a retrospective series of 137 patients. Cytogenetics were normal in 117 patients (85%) and displayed a -Y abnormality in five patients (7% of male patients), and other chromosomal abnormalities in 15 patients (11%). The most frequent cytogenetic anomalies were trisomy 8 (n = 4), trisomy 9 (n = 2), deletion 20q (n = 2) and chromosomal 1 abnormalities (n = 2). Parameters that were significantly associated with abnormal cytogenetics included age > or = 60 yr (P = 0.02), but not JAK2V617F allele burden, thrombosis, hemorrhage, leukemic/fibrotic transformation, or survival. We conclude that cytogenetic anomalies occur infrequently at PV diagnosis and do not confer an adverse outcome.
- Publication
European journal of haematology, 2008, Vol 80, Issue 3, p197
- ISSN
1600-0609
- Publication type
Journal Article
- DOI
10.1111/j.1600-0609.2007.01003.x