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- Title
Hydrops lysosomalis generalisatus--an underestimated side effect of hydroxyethyl starch therapy?
- Authors
Schmidt-Hieber, Martin; Loddenkemper, Christoph; Schwartz, Stefan; Arntz, Gesine; Thiel, Eckhard; Notter, Michael
- Abstract
Hydroxyethyl starch (HES) is usually considered to be associated with limited side effects. Generalized foamy cell macrophage syndrome after HES therapy has rarely been reported since Schaefer first described it as 'hydrops lysosomalis generalisatus' in 1982. We present a 19-yr-old male who received large amounts of HES. A bone marrow and a liver biopsy were performed because of persistent thrombocytopenia and liver dysfunction. We found severe infiltration of foamy cell degenerated macrophages in both organ systems, indicating that sequelae of HES therapy have to be included in the differential diagnosis of bone marrow and liver dysfunction.
- Publication
European journal of haematology, 2006, Vol 77, Issue 1, p83
- ISSN
0902-4441
- Publication type
Journal Article
- DOI
10.1111/j.1600-0609.2006.00657.x