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- Title
FISH for MYC amplification and anti-MYC immunohistochemistry: useful diagnostic tools in the assessment of secondary angiosarcoma and atypical vascular proliferations.
- Authors
Fernandez, Anthony P; Sun, Yang; Tubbs, Raymond R; Goldblum, John R; Billings, Steven D
- Abstract
Secondary angiosarcoma and benign but microscopically atypical vascular proliferations (herein referred to as atypical vascular lesion or AVL) are rare consequences of radiation therapy and/or chronic lymphedema most commonly seen in breast cancer patients. Differentiating angiosarcoma from AVL can be difficult due to overlapping clinical and microscopic features. Recently, amplification of MYC has been associated with 55-100% of secondary angiosarcomas but is reportedly absent in AVL. We examined a series of secondary angiosarcoma and AVL for MYC amplification by fluorescence in situ hybridization (FISH) and expression by immunohistochemistry to investigate the diagnostic utility for discriminating angiosarcoma from AVL.
- Publication
Journal of cutaneous pathology, 2012, Vol 39, Issue 2, p234
- ISSN
1600-0560
- Publication type
Journal Article
- DOI
10.1111/j.1600-0560.2011.01843.x