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- Title
Immunoreactivity of CD99 in invasive malignant melanoma.
- Authors
Wilkerson, Anne E; Glasgow, Meriden A; Hiatt, Kim M
- Abstract
CD99, also known as p30/32, is a glycoprotein product of the MIC2 gene. It was originally utilized in immunohistochemistry as a unique marker for Ewing sarcoma, other primitive neuroectodermal tumors, and subsequently in other tumors. Its expression in malignant melanoma (MM) has not been well documented, with just two isolated cases of MM recently reported. Recent studies have documented CD99 expression in a significant percentage of atypical fibroxanthomas (AFX), posing potential diagnostic problems in differentiating these two entities. As mistaking MM for AFX based on immunohistochemical staining pattern has significant consequences, we sought to determine the percentage of invasive MM in our archives that have this staining pattern.
- Publication
Journal of cutaneous pathology, 2006, Vol 33, Issue 10, p663
- ISSN
0303-6987
- Publication type
Journal Article
- DOI
10.1111/j.1600-0560.2006.00524.x