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- Title
The modulation of skin irritation.
- Abstract
Irritant contact dermatitis (lCD) is a muitifactorial disease, the onset and modulation of which depend on both endogenous and exogenous factors. Among the former, age, race, site, sex and history of dermatitis may all be important. Such variables can now readily be quantified by objective noninvasive techniques, such as measurement of transepidermal water loss (TEWL). Moreover, effects of irritants on the epidermis are related to the particular chemical properties of each molecule, contributing further to clinical heterogeneity. Release of cytokines and mediators may be initiated by a number of cells, including living keratinocytes and those of the stratum corneum, thus modulating inflammation and repair. Furthermore, differences in mechanisms of inflammation between acute and chronic LCD may exist, the former being characterized predominantly by inflammation, the latter by hyperproliferation and transient hyperkeratosis. These findings may explain the complexity and difficulty of investigating LCD. Better understanding and quantification of these mechanisms may lead to identification of high-risk individuals and more effective prevention and treatment.
- Publication
Contact Dermatitis (01051873), 1994, Vol 31, Issue 5, p281
- ISSN
0105-1873
- Publication type
Academic Journal
- DOI
10.1111/j.1600-0536.1994.tb02019.x