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- Title
Association of salivary lysozyme and C-reactive protein with metabolic syndrome.
- Authors
Qvarnstrom, Markku; Janket, Sok-Ja; Jones, Judith A.; Jethwani, Kamal; Nuutinen, Pekka; Garcia, Raul I.; Baird, Alison E.; Van Dyke, Thomas E.; Meurman, Jukka H.
- Abstract
Qvarnstrom M, Janket S-J, Jones JA, Jethwani K, Nuutinen P, Garcia RI, Baird AE, Van Dyke TE and Meurman JH. Association of salivary lysozyme and C-reactive protein with metabolic syndrome. J Clin Periodontol 2010; 37: 805–811. doi: 10.1111/j.1600-051X.2010.01605.x. Introduction: Salivary lysozyme (SLZ) is a proteolytic enzyme secreted by oral leucocytes and contains a domain that has an affinity to advanced glycation end products (AGE). Thus, we hypothesized that SLZ would be associated with metabolic syndrome (metS), a pro-inflammatory state. Methods: Utilizing cross-sectional data from 250 coronary artery disease (CAD) and 250 non-CAD patients, the association of SLZ with metS was tested by logistic regression analyses controlling for age, sex, smoking, total cholesterol and C-reactive protein (CRP) levels. The analyses were stratified by CAD status to control for the possible effects of CAD. Results: MetS was found in 122 persons. The adjusted odds ratio (OR) for metS associated with the highest quartile of SLZ was 1.95 with 95% confidence interval (CI) 1.20–3.12, p-value=0.007, compared with the lower three quartiles combined. Among the 40 subjects with metS but without CAD, the OR was 1.63 (CI: 0.64–4.15, p=0.31), whereas in the CAD group, SLZ was significantly associated with metS [OR=1.96 (1.09–3.52), p=0.02]. In both subgroups, CRP was not significantly associated with metS. Conclusion: SLZ was significantly associated with metS (OR=1.95) independent of CRP level. Future longitudinal research is warranted.
- Publication
Journal of Clinical Periodontology, 2010, Vol 37, Issue 9, p805
- ISSN
0303-6979
- Publication type
Academic Journal
- DOI
10.1111/j.1600-051X.2010.01605.x