We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Innate recognition of intracellular pathogens: detection and activation of the first line of defense.
- Authors
Rasmussen, Simon B; Reinert, Line S; Paludan, Søren R
- Abstract
The innate immune system constitutes the first line of defense against infections and is also important for initiating the development of an adaptive immune response. The innate immune system recognizes microbial infection through germline-encoded pattern recognition receptors, which are responsible for decoding the microbial fingerprint and activating an appropriate response against the invading pathogen. In this review, we present and discuss current knowledge on how the innate immune system recognizes intracellular pathogens, activates intracellular signaling, induces gene expression, and orchestrates the microbicidal response against pathogens with a habitat within host cells.
- Publication
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2009, Vol 117, Issue 5-6, p323
- ISSN
1600-0463
- Publication type
Journal Article
- DOI
10.1111/j.1600-0463.2009.02456.x