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- Title
Cyanobacterial neurotoxin BMAA in ALS and Alzheimer's disease.
- Authors
Pablo, J; Banack, S A; Cox, P A; Johnson, T E; Papapetropoulos, S; Bradley, W G; Buck, A; Mash, D C
- Abstract
The aim of this study was to screen for and quantify the neurotoxic amino acid beta-N-methylamino-L-alanine (BMAA) in a cohort of autopsy specimens taken from Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and non-neurological controls. BMAA is produced by cyanobacteria found in a variety of freshwater, marine, and terrestrial habitats. The possibility of geographically broad human exposure to BMAA had been suggested by the discovery of BMAA in brain tissues of Chamorro patients with ALS/Parkinsonism dementia complex from Guam and more recently in AD patients from North America. These observations warranted an independent study of possible BMAA exposures outside of the Guam ecosystem.
- Publication
Acta neurologica Scandinavica, 2009, Vol 120, Issue 4, p216
- ISSN
1600-0404
- Publication type
Journal Article
- DOI
10.1111/j.1600-0404.2008.01150.x