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- Title
How do tenascins influence the birth and life of a malignant cell?
- Authors
Brellier, Florence; Chiquet-Ehrismann, Ruth
- Abstract
Tenascins are large glycoproteins found in embryonic and adult extracellular matrices. Of the four family members, two have been shown to be overexpressed in the microenvironment of solid tumours: tenascin-C and tenascin-W. The regular presence of these proteins in tumours suggests a role in tumourigenesis, which has been investigated intensively for tenascin-C and recently for tenascin-W as well. In this review, we follow a malignant cell starting from its birth through its potential metastatic journey and describe how tenascin-C and tenascin-W contribute to these successive steps of tumourigenesis. We consider the importance of the mechanical aspect in tenascin signalling. Furthermore, we discuss studies describing tenascin-C as an important component of stem cell niches and present examples reporting its role in cancer therapy resistance.
- Publication
Journal of cellular and molecular medicine, 2012, Vol 16, Issue 1, p32
- ISSN
1582-4934
- Publication type
Journal Article
- DOI
10.1111/j.1582-4934.2011.01360.x