We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
DNA damage-induced gene expression in Saccharomyces cerevisiae.
- Authors
Fu, Yu; Pastushok, Landon; Xiao, Wei
- Abstract
After exposure to DNA-damaging agents, both prokaryotic and eukaryotic cells activate stress responses that result in specific alterations in patterns of gene expression. Bacteria such as Escherichia coli possess both lesion-specific responses as well as an SOS response to general DNA damage, and the molecular mechanisms of these responses are well studied. Mechanisms of DNA damage response in lower eukaryotes such as Saccharomyces cerevisiae are apparently different from those in bacteria. It becomes clear that many DNA damage-inducible genes are coregulated by the cell-cycle checkpoint, a signal transduction cascade that coordinates replication, repair, transcription and cell-cycle progression. On the other hand, among several well-characterized yeast DNA damage-inducible genes, their effectors and mechanisms of transcriptional regulation are rather different. This review attempts to summarize the current state of knowledge on the molecular mechanisms of DNA damage-induced transcriptional regulation in this model lower eukaryotic microorganism.
- Publication
FEMS microbiology reviews, 2008, Vol 32, Issue 6, p908
- ISSN
0168-6445
- Publication type
Journal Article
- DOI
10.1111/j.1574-6976.2008.00126.x