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- Title
RNA thermometers.
- Authors
Narberhaus, Franz; Waldminghaus, Torsten; Chowdhury, Saheli
- Abstract
Temperature is an important parameter that free-living cells monitor constantly. The expression of heat-shock, cold-shock and some virulence genes is coordinated in response to temperature changes. Apart from protein-mediated transcriptional control mechanisms, translational control by RNA thermometers is a widely used regulatory strategy. RNA thermometers are complex RNA structures that change their conformation in response to temperature. Most, but not all, RNA thermometers are located in the 5'-untranslated region and mask ribosome-binding sites by base pairing at low temperatures. Melting of the structure at increasing temperature permits ribosome access and translation initiation. Different cis-acting RNA thermometers and a trans-acting thermometer will be presented.
- Publication
FEMS microbiology reviews, 2006, Vol 30, Issue 1, p3
- ISSN
0168-6445
- Publication type
Journal Article
- DOI
10.1111/j.1574-6976.2005.004.x