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- Title
Porphyromonas gingivalis infection and cell death in human aortic endothelial cells.
- Authors
Roth, Georg A; Ankersmit, Hendrik J; Brown, Vinette B; Papapanou, Panos N; Schmidt, Ann Marie; Lalla, Evanthia
- Abstract
Porphyromonas gingivalis is a periodontal pathogen that promotes a proatherogenic response in endothelial cells. Cell death responses of human aortic endothelial cells to P. gingivalis at various multiplicities of infection (MOI) were investigated by assessment of cell detachment, histone-associated DNA fragmentation, lactate dehydrogenase release and ADP:ATP ratio. Porphyromonas gingivalis at MOI 1:10-1:100 did not have a cytotoxic effect, but induced apoptotic cell death at MOI 1:500 and 1:1000. Monocyte chemoattractant protein-1 production was significantly enhanced by P. gingivalis at MOI 1:100. At higher MOI, at least in vitro, P. gingivalis mediates endothelial apoptosis, thereby potentially amplifying proatherogenic mechanisms in the perturbed vasculature.
- Publication
FEMS microbiology letters, 2007, Vol 272, Issue 1, p106
- ISSN
0378-1097
- Publication type
Journal Article
- DOI
10.1111/j.1574-6968.2007.00736.x