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- Title
Rafting with cholera toxin: endocytosis and trafficking from plasma membrane to ER.
- Authors
Chinnapen, Daniel J-F; Chinnapen, Himani; Saslowsky, David; Lencer, Wayne I
- Abstract
Cholera toxin (CT), and members of the AB(5) family of toxins enter host cells and hijack the cell's endogenous pathways to induce toxicity. CT binds to a lipid receptor on the plasma membrane (PM), ganglioside GM1, which has the ability to associate with lipid rafts. The toxin can then enter the cell by various modes of receptor-mediated endocytosis and traffic in a retrograde manner from the PM to the Golgi and the endoplasmic reticulum (ER). Once in the ER, a portion of the toxin is unfolded and retro-translocated to the cytosol so as to induce disease. GM1 is the vehicle that carries CT from PM to ER. Thus, the toxin pathway from PM to ER is a lipid-based sorting pathway, which is potentially meditated by the determinants of the GM1 ganglioside structure itself.
- Publication
FEMS microbiology letters, 2007, Vol 266, Issue 2, p129
- ISSN
0378-1097
- Publication type
Journal Article
- DOI
10.1111/j.1574-6968.2006.00545.x