We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
DNA repair profiles of disease-associated isolates of Neisseria meningitidis.
- Authors
Davidsen, Tonje; Amundsen, Erik Koldberg; Rødland, Einar Andreas; Tønjum, Tone
- Abstract
Neisseria meningitidis, or the meningococcus, is the source of significant morbidity and mortality in humans worldwide. Even though mutability has been linked to the occurrence of outbreaks of epidemic disease, meningococcal DNA repair pathways are poorly delineated. For the first time, a collection of meningococcal disease-associated isolates has been demonstrated to express constitutively the DNA glycosylases MutY and Fpg in vivo. DNA sequence analysis showed considerable variability in the deduced amino acid sequences of MutS and Fpg, while MutY and RecA were highly conserved. Interestingly, multi-locus sequence typing demonstrated a putative link between the pattern of amino acid substitutions and levels of spontaneous mutagenicity in meningococcal strains. These results provide a basis for further studies aimed at resolving the genotype/phenotype relationships of meningococcal genome variability and mutator activity.
- Publication
FEMS immunology and medical microbiology, 2007, Vol 49, Issue 2, p243
- ISSN
0928-8244
- Publication type
Journal Article
- DOI
10.1111/j.1574-695X.2006.00195.x