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- Title
The presence of small intestinal intraepithelial gamma/delta T-lymphocytes is inversely correlated with lymphoma development in refractory celiac disease.
- Authors
Verbeek, Wieke H M; von Blomberg, B Mary E; Scholten, Petra E T; Kuik, D Joop; Mulder, Chris J J; Schreurs, Marco W J
- Abstract
In refractory celiac disease (RCD) type II, a phenotypically aberrant (CD7+ CD3- CD4/8-cytoplasmicCD3+) intraepithelial lymphocyte (IEL) population is present, and 50-60% of these patients develop enteropathy-associated T-cell lymphoma (EATL). TCRgammadelta+ IELs play an important role in mucosal repair, homeostasis, and tumor surveillance. Recently, human small intestinal TCRgammadelta+ IELs were shown to have regulatory potential in uncomplicated celiac disease (CD).
- Publication
The American journal of gastroenterology, 2008, Vol 103, Issue 12, p3152
- ISSN
1572-0241
- Publication type
Journal Article
- DOI
10.1111/j.1572-0241.2008.02213.x