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- Title
Genetic background of celiac disease and its clinical implications.
- Authors
Wolters, Victorien M; Wijmenga, Cisca
- Abstract
Celiac disease (CD) is a complex genetic disorder with multiple contributing genes. Linkage studies have identified several genomic regions that probably contain CD susceptibility genes. The most important genetic factors identified are HLA-DQ2 and HLA-DQ8, which are necessary but not sufficient to predispose to CD. The associations found in non-HLA genomewide linkage and association studies are much weaker. This might be because a large number of non-HLA genes contributes to the pathogenesis of CD. Hence, the contribution of a single predisposing non-HLA gene might be quite modest. Practically all CD patients carry HLA-DQ2 or HLA-DQ8, while the absence of these molecules has a negative predictive value for CD close to 100%. Genetic risk profiles for CD would be helpful in clinical practice for predicting disease susceptibility and progression.
- Publication
The American journal of gastroenterology, 2008, Vol 103, Issue 1, p190
- ISSN
0002-9270
- Publication type
Journal Article
- DOI
10.1111/j.1572-0241.2007.01471.x