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- Title
Prevention of ulcers by esomeprazole in at-risk patients using non-selective NSAIDs and COX-2 inhibitors.
- Authors
Scheiman, James M; Yeomans, Neville D; Talley, Nicholas J; Vakil, Nimish; Chan, Francis K L; Tulassay, Zsolt; Rainoldi, Jorge L; Szczepanski, Leszek; Ung, Kjell-Arne; Kleczkowski, Dariusz; Ahlbom, Henrik; Naesdal, Jørgen; Hawkey, Christopher
- Abstract
Proton pump inhibitors reduce ulcer recurrence in non-steroidal anti-inflammatory drug (NSAID) users, but their impact in at-risk ulcer-free patients using the current spectrum of prescribed agents has not been clearly defined. We assessed esomeprazole for ulcer prevention in at-risk patients (> or = 60 yr and/or ulcer history) taking NSAIDs, including COX-2 inhibitors. Such studies are particularly relevant, given that concerns regarding adverse cardiovascular outcomes among COX-2 inhibitor users may prompt re-evaluation of their use.
- Publication
The American journal of gastroenterology, 2006, Vol 101, Issue 4, p701
- ISSN
0002-9270
- Publication type
Journal Article
- DOI
10.1111/j.1572-0241.2006.00499.x