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- Title
Immunosuppressive therapy in Whipple's disease patients is associated with the appearance of gastrointestinal manifestations.
- Authors
Mahnel, René; Kalt, Anja; Ring, Sabine; Stallmach, Andreas; Strober, Warren; Marth, Thomas
- Abstract
Whipple's disease is a rare chronic disorder, which is caused by systemic infection with Tropheryma whipplei. The first symptom of Whipple's disease usually is a nondestructive polyarthritis resembling in many aspects seronegative rheumatoid arthritis. This polyarticular inflammatory arthropathy preceding the diagnosis of Whipple's disease for several years frequently is treated with nonsteroidal antiinflammatory drugs (NSAIDs) and with immunosuppressive therapy. There is evidence that altered immune functions play a role in the manifestation of the disease and that Whipple's disease is associated with opportunistic infections. We therefore asked whether immunosuppressive treatment for arthropathy may alter the course of Whipple's disease.
- Publication
The American journal of gastroenterology, 2005, Vol 100, Issue 5, p1167
- ISSN
0002-9270
- Publication type
Journal Article
- DOI
10.1111/j.1572-0241.2005.40128.x