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- Title
Hepatic steatosis in Dunnigan-type familial partial lipodystrophy.
- Authors
Lüdtke, Angelika; Genschel, Janine; Brabant, Georg; Bauditz, Jürgen; Taupitz, Matthias; Koch, Martin; Wermke, Wolfram; Worman, Howard J; Schmidt, Hartmut H-J
- Abstract
Characterization of familial clusters of subjects with metabolic derangements predisposing to hepatic steatosis and nonalcoholic steatohepatitis could facilitate genomic studies to identify risk factors for their development. Dunnigan-type familial partial lipodystrophy (FPLD) is an autosomal dominantly inherited disorder caused by mutations in the LMNA gene. Affected subjects have loss of subcutaneous fat from the extremities and symptoms similar to those characterizing the metabolic syndrome, including insulin resistance and dyslipidemia. The goal of this study was to determine the prevalence of steatosis in subjects with FPLD.
- Publication
The American journal of gastroenterology, 2005, Vol 100, Issue 10, p2218
- ISSN
0002-9270
- Publication type
Journal Article
- DOI
10.1111/j.1572-0241.2005.00234.x