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- Title
Serologic testing with ANCA, ASCA, and anti-OmpC in children and young adults with Crohn's disease and ulcerative colitis: diagnostic value and correlation with disease phenotype.
- Authors
Zholudev, Anna; Zurakowski, David; Young, Wes; Leichtner, Alan; Bousvaros, Athos
- Abstract
Serologic testing is increasingly being utilized to evaluate children with suspected inflammatory bowel disease (IBD). The aim of this paper was to evaluate the sensitivity and specificity of a currently available panel involving four antibodies: deoxyribonuclease (DNase)-sensitive perinuclear antineutrophil cytoplasmic antibody (DNase-sensitive pANCA), IgA and IgG antibodies to Saccharomyces cerevisiae (IgA and IgG ASCA), and antibody to Escherichia coli outer membrane porin (anti-OmpC). We also wished to determine whether antibody levels correlated with disease activity, and whether a specific antibody pattern correlated with location and outcome of disease in children.
- Publication
The American journal of gastroenterology, 2004, Vol 99, Issue 11, p2235
- ISSN
0002-9270
- Publication type
Journal Article
- DOI
10.1111/j.1572-0241.2004.40369.x