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- Title
Progressive familial intrahepatic cholestasis: partial biliary diversion normalizes serum lipids and improves growth in noncirrhotic patients.
- Authors
Melter, M; Rodeck, B; Kardorff, R; Hoyer, P F; Petersen, C; Ballauff, A; Brodehl, J
- Abstract
Progressive familial intrahepatic cholestasis (PFIC) usually presents with pruritus, jaundice, hepatomegaly, and growth failure. A group of PFIC is recognized by marked elevation of total serum bile acids, decreased serum apolipoprotein A-1, and high-density lipoprotein, but normal gamma-glutamyltranspeptidase and cholesterol. Although medical therapy generally fails, partial external biliary diversion (DIV) has been used with promising results for cholestasis. However, little has been reported of its effect on linear growth, synthetic liver function, and lipid metabolism.
- Publication
The American journal of gastroenterology, 2000, Vol 95, Issue 12, p3522
- ISSN
0002-9270
- Publication type
Journal Article
- DOI
10.1111/j.1572-0241.2000.03370.x