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- Title
Differential equation modeling of HIV viral fitness experiments: model identification, model selection, and multimodel inference.
- Authors
Miao, Hongyu; Dykes, Carrie; Demeter, Lisa M; Wu, Hulin
- Abstract
Many biological processes and systems can be described by a set of differential equation (DE) models. However, literature in statistical inference for DE models is very sparse. We propose statistical estimation, model selection, and multimodel averaging methods for HIV viral fitness experiments in vitro that can be described by a set of nonlinear ordinary differential equations (ODE). The parameter identifiability of the ODE models is also addressed. We apply the proposed methods and techniques to experimental data of viral fitness for HIV-1 mutant 103N. We expect that the proposed modeling and inference approaches for the DE models can be widely used for a variety of biomedical studies.
- Publication
Biometrics, 2009, Vol 65, Issue 1, p292
- ISSN
1541-0420
- Publication type
Journal Article
- DOI
10.1111/j.1541-0420.2008.01059.x