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- Title
ATX-II effects on the apparent location of M cells in a computational model of a human left ventricular wedge.
- Authors
Dos Santos, Rodrigo Weber; Otaviano Campos, Fernando; Neumann Ciuffo, Leandro; Nygren, Anders; Giles, Wayne; Koch, Hans
- Abstract
The apparent location of the myocytes (M cells) with the longest action potential duration (APD) in a canine left ventricular (LV) wedge have been reported to shift after application of a sea anemone toxin, ATX-II. This toxin slows inactivation of I(Na) and thus prolongs APD. Thus, M cells may exhibit dynamic functional states, rather than being a static, anatomically discrete, myocyte population. In this study, we attempted to further define and understand this phenomenon using a mathematical model of the human ventricular myocyte action potential incorporated into an in silico "wedge" preparation. Our simulations demonstrate that even under conditions of a fixed population and ratio of epicardial, M, and endocardial myocytes, the apparent anatomical position (transmural location) of the myocytes with the longest APD can shift following ATX-II treatment. This arises because the ATX-II effect, modeled as a small increase in the late or persistent Na(+) current, and consequent prolongation of APD significantly changes the electrotonic interactions between ventricular myocytes in this LV wedge preparation.
- Publication
Journal of cardiovascular electrophysiology, 2006, Vol 17 Suppl 1, pS86
- ISSN
1045-3873
- Publication type
Journal Article
- DOI
10.1111/j.1540-8167.2006.00389.x