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- Title
Isolated tramadol overdose associated with Brugada ECG pattern.
- Authors
Cole, Jon B; Sattiraju, Srinivasan; Bilden, Elisabeth F; Asinger, Richard W; Bertog, Stefan C
- Abstract
Tramadol is a commonly prescribed synthetic opioid analgesic. In humans, electrocardiogram (ECG) changes consistent with sodium-channel blockade have not been described in overdoses with tramadol. We report a case of isolated tramadol overdose associated with a Brugada ECG pattern. A review of the literature reveals no previous human cases of tramadol overdose causing ECG changes consistent with sodium-channel blockade. However, in vitro blockade of sodium-channels has been demonstrated with high concentrations of tramadol. Tramadol overdose should be recognized as a cause for the manifestation of a Brugada ECG pattern in the setting of suicidal intoxication.
- Publication
Pacing and clinical electrophysiology : PACE, 2012, Vol 35, Issue 8, pe219
- ISSN
1540-8159
- Publication type
Journal Article
- DOI
10.1111/j.1540-8159.2010.02924.x