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- Title
Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation.
- Authors
Ammollo, C T; Semeraro, F; Xu, J; Esmon, N L; Esmon, C T
- Abstract
Histones are basic proteins that contribute to cell injury and tissue damage when released into the extracellular space. They have been attributed a prothrombotic activity, because their injection into mice induces diffuse microvascular thrombosis. The protein C-thrombomodulin (TM) system is a fundamental regulator of coagulation, particularly in the microvasculature, and its activity can be differentially influenced by interaction with several cationic proteins.
- Publication
Journal of thrombosis and haemostasis : JTH, 2011, Vol 9, Issue 9, p1795
- ISSN
1538-7836
- Publication type
Journal Article
- DOI
10.1111/j.1538-7836.2011.04422.x