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Title
Activated protein C protects against myocardial ischemic/reperfusion injury through AMP-activated protein kinase signaling.
Authors
Wang, J; Yang, L; Rezaie, A R; Li, J
Abstract
Activated protein C (APC) is a vitamin K-dependent plasma serine protease that down-regulates clotting and inflammatory pathways. It is known that APC exerts a cardioprotective effect by decreasing apoptosis of cardiomyocytes and inhibiting expression of inflammatory mediators after myocardial ischemia.
Publication
Journal of thrombosis and haemostasis : JTH, 2011, Vol 9, Issue 7, p1308