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- Title
The thrombomodulin analog Solulin promotes reperfusion and reduces infarct volume in a thrombotic stroke model.
- Authors
Su, E J; Geyer, M; Wahl, M; Mann, K; Ginsburg, D; Brohmann, H; Petersen, K U; Lawrence, D A
- Abstract
Currently there is no approved anticoagulant for treating acute stroke. This is largely because of concern for hemorrhagic complications, and suggests a critical need for safer anticoagulants. Solulin is a soluble analog of the endothelial cell receptor thrombomodulin, able to bind free thrombin and convert it to an activator of the anticoagulant, protein C.
- Publication
Journal of thrombosis and haemostasis : JTH, 2011, Vol 9, Issue 6, p1174
- ISSN
1538-7836
- Publication type
Journal Article
- DOI
10.1111/j.1538-7836.2011.04269.x