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- Title
Coagulation procofactor activation by factor XIa.
- Authors
Whelihan, M F; Orfeo, T; Gissel, M T; Mann, K G
- Abstract
In the extrinsic pathway, the essential procofactors factor (F) V and FVIII are activated to FVa and FVIIIa by thrombin. In the contact pathway and its clinical diagnostic test, the activated partial thromboplastin time (APTT) assay, the sources of procofactor activation are unknown. In the APTT assay, FXII is activated on a negatively charged surface and proceeds to activate FXI, which activates FIX upon the addition of Ca(2+). FIXa feeds thrombin generation through activation of FX. FIXa is an extremely poor catalyst in the absence of its FVIIIa cofactor, which, in the intrinsic FXase complex, increases FXa generation by approximately 10(7). One potential APTT procofactor activator in this setting is FXIa.
- Publication
Journal of thrombosis and haemostasis : JTH, 2010, Vol 8, Issue 7, p1532
- ISSN
1538-7836
- Publication type
Journal Article
- DOI
10.1111/j.1538-7836.2010.03899.x