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- Title
A new role for the A2b adenosine receptor in regulating platelet function.
- Authors
Yang, D; Chen, H; Koupenova, M; Carroll, S H; Eliades, A; Freedman, J E; Toselli, P; Ravid, K
- Abstract
Activation of platelets is a critical component of atherothrombosis and plays a central role in the progression of unstable cardiovascular syndromes. Adenosine, acting through adenosine receptors, increases intracellular cAMP levels and inhibits platelet aggregation. The A2a adenosine receptor has already been recognized as a mediator of adenosine-dependent effects on platelet aggregation, and here we present a new role for the A2b adenosine receptor (A2bAR) in this process.
- Publication
Journal of thrombosis and haemostasis : JTH, 2010, Vol 8, Issue 4, p817
- ISSN
1538-7836
- Publication type
Journal Article
- DOI
10.1111/j.1538-7836.2010.03769.x