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- Title
Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis.
- Authors
Przyklenk, K; Frelinger, A L, 3rd; Linden, M D; Whittaker, P; Li, Y; Barnard, M R; Adams, J; Morgan, M; Al-Shamma, H; Michelson, A D
- Abstract
Release of serotonin and activation of serotonin 5HT2A receptors on platelet surfaces is a potent augmentative stimulus for platelet aggregation. However, earlier-generation serotonin receptor antagonists were not successfully exploited as antiplatelet agents, possibly owing to their lack of specificity for the 5HT2A receptor subtype.
- Publication
Journal of thrombosis and haemostasis : JTH, 2010, Vol 8, Issue 2, p331
- ISSN
1538-7836
- Publication type
Journal Article
- DOI
10.1111/j.1538-7836.2009.03693.x