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- Title
Rap1b is critical for glycoprotein VI-mediated but not ADP receptor-mediated alpha2beta1 activation.
- Authors
Wang, Z; Holly, S P; Larson, M K; Liu, J; Yuan, W; Chrzanowska-Wodnicka, M; White, G C, 2nd; Parise, L V
- Abstract
The platelet alpha2beta1 integrin functions as both an adhesion and signaling receptor upon exposure to collagen. Recent studies have indicated that alpha2beta1 function can be activated via inside-out signaling, similar to the prototypical platelet integrin alphaIIbbeta3. However, signaling molecules that regulate alpha2beta1 activation in platelets are not well defined. A strong candidate molecule is the small GTPase Rap1b, the dominant platelet isoform of Rap1, which regulates alphaIIbbeta3 activation.
- Publication
Journal of thrombosis and haemostasis : JTH, 2009, Vol 7, Issue 4, p693
- ISSN
1538-7836
- Publication type
Journal Article
- DOI
10.1111/j.1538-7836.2009.03289.x