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- Title
Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel.
- Authors
Brandt, J T; Close, S L; Iturria, S J; Payne, C D; Farid, N A; Ernest, C S, 2nd; Lachno, D R; Salazar, D; Winters, K J
- Abstract
Thienopyridines are metabolized to active metabolites that irreversibly inhibit the platelet P2Y(12) adenosine diphosphate receptor. The pharmacodynamic response to clopidogrel is more variable than the response to prasugrel, but the reasons for variation in response to clopidogrel are not well characterized.
- Publication
Journal of thrombosis and haemostasis : JTH, 2007, Vol 5, Issue 12, p2429
- ISSN
1538-7933
- Publication type
Journal Article
- DOI
10.1111/j.1538-7836.2007.02775.x