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- Title
Systemic administration of anti-urokinase plasminogen activator receptor monoclonal antibodies induces hepatic fibrin deposition in tissue-type plasminogen activator deficient mice.
- Authors
Jögi, A; Pass, J; Høyer-Hansen, G; Lund, L R; Nielsen, B S; Danø, K; Rømer, J
- Abstract
Degradation of extracellular matrix proteins, such as fibrin, is pivotal to tumor invasion. Inhibition of the interaction between urokinase plasminogen activator (u-PA) and its receptor (u-PAR), and hence pro-u-PA activation, is an attractive approach to anti-invasive cancer therapy. A number of inhibitors exist for the human system, but because of species specificity none of these are efficient in mice. We have recently generated an inhibitory monoclonal antibody (mAb) against mouse u-PAR (mR1) by immunization of u-PAR-deficient mice.
- Publication
Journal of thrombosis and haemostasis : JTH, 2007, Vol 5, Issue 9, p1936
- ISSN
1538-7933
- Publication type
Journal Article
- DOI
10.1111/j.1538-7836.2007.02653.x