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- Title
Differential effects of high prothrombin levels on thrombin generation depending on the cause of the hyperprothrombinemia.
- Authors
Castoldi, E; Simioni, P; Tormene, D; Thomassen, M C L G D; Spiezia, L; Gavasso, S; Rosing, J
- Abstract
Hyperprothrombinemia, resulting from the prothrombin G20210A mutation or other causes, is associated with activated protein C (APC) resistance and increased thrombosis risk. When high prothrombin levels are a result of increased hepatic biosynthesis, these effects may be counteracted by concomitantly increased levels of the anticoagulant factors (particularly protein S). Differently, in prothrombin G20210A carriers only prothrombin levels are elevated.
- Publication
Journal of thrombosis and haemostasis : JTH, 2007, Vol 5, Issue 5, p971
- ISSN
1538-7933
- Publication type
Journal Article
- DOI
10.1111/j.1538-7836.2007.02448.x