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- Title
Low-density lipoprotein receptor-related protein 1 polymorphism 663 C > T affects clotting factor VIII activity and increases the risk of venous thromboembolism.
- Authors
Vormittag, R; Bencur, P; Ay, C; Tengler, T; Vukovich, T; Quehenberger, P; Mannhalter, C; Pabinger, I
- Abstract
Clotting factor (F) VIII is an independent risk factor for primary and recurrent venous thromboembolism (VTE). The causes for high plasma FVIII levels are not fully understood, but an involvement of genetic factors has been demonstrated. A multifunctional endocytic receptor, low-density lipoprotein receptor-related protein 1 (LRP1), mediates cellular uptake and subsequent degradation of FVIII and may contribute to variations in FVIII levels.
- Publication
Journal of thrombosis and haemostasis : JTH, 2007, Vol 5, Issue 3, p497
- ISSN
1538-7933
- Publication type
Journal Article
- DOI
10.1111/j.1538-7836.2007.02337.x