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- Title
Activity and regulation of factor VIIa analogs with increased potency at the endothelial cell surface.
- Authors
Ghosh, S; Ezban, M; Persson, E; Pendurthi, U; Hedner, U; Rao, L V M
- Abstract
Variants of recombinant factor VIIa (rFVIIa) with increased intrinsic activity have been developed to improve efficacy in the treatment of bleeding disorders in the future. The increased potency of FVIIa variants was demonstrated in limited in vitro and in vivo studies. However, further characterization of FVIIa variants is needed to evaluate their potential clinical use.
- Publication
Journal of thrombosis and haemostasis : JTH, 2007, Vol 5, Issue 2, p336
- ISSN
1538-7933
- Publication type
Journal Article
- DOI
10.1111/j.1538-7836.2007.02308.x