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- Title
Dopamine modulates von Willebrand factor secretion in endothelial cells via D2-D4 receptors.
- Authors
Zarei, S; Frieden, M; Rubi, B; Villemin, P; Gauthier, B R; Maechler, P; Vischer, U M
- Abstract
von Willebrand factor (VWF) is acutely released from endothelial cells in response to numerous calcium-raising agents (e.g. thrombin, histamine) and cAMP-raising agents (e.g. epinephrine, adenosine, vasopressin). In contrast, very few inhibitors of endothelial VWF secretion have been described. The neurotransmitter dopamine is a modulator of exocytosis in several endocrine cells, and is possibly involved in the regulation of several endothelial cell functions. We therefore investigated the effect of dopamine on endothelial VWF secretion.
- Publication
Journal of thrombosis and haemostasis : JTH, 2006, Vol 4, Issue 7, p1588
- ISSN
1538-7933
- Publication type
Journal Article
- DOI
10.1111/j.1538-7836.2006.01998.x