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- Title
Megakaryocytes derived from human embryonic stem cells: a genetically tractable system to study megakaryocytopoiesis and integrin function.
- Authors
Gaur, M; Kamata, T; Wang, S; Moran, B; Shattil, S J; Leavitt, A D
- Abstract
The platelet fibrinogen receptor, a heterodimer consisting of integrin subunits alpha(IIb) and beta(3), is required for platelet aggregation, spreading, and hemostasis. Platelet agonists such as thrombin and adenosine diphosphate (ADP) lead to the activation of alpha(IIb)beta(3), thereby enhancing its affinity and avidity for binding fibrinogen (inside-out signaling). Furthermore, fibrinogen binding to alpha(IIb)beta(3) triggers cytoskeletal changes and granule release (outside-in signaling).
- Publication
Journal of thrombosis and haemostasis : JTH, 2006, Vol 4, Issue 2, p436
- ISSN
1538-7933
- Publication type
Journal Article
- DOI
10.1111/j.1538-7836.2006.01744.x