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- Title
Thrombotic phenotype of mice with a combined deficiency in plasminogen activator inhibitor 1 and vitronectin.
- Authors
Koschnick, S; Konstantinides, S; Schäfer, K; Crain, K; Loskutoff, D J
- Abstract
The role of vitronectin (VN) in thrombosis is not fully understood, primarily because this adhesive glycoprotein not only stabilizes plasminogen activator inhibitor 1 (PAI-1) and thus protects fibrin from premature lysis, but also because it binds to platelet integrins and may influence platelet aggregation. The absence of quantitative approaches to characterize the thrombi formed in animal models under different conditions further complicates this analysis.
- Publication
Journal of thrombosis and haemostasis : JTH, 2005, Vol 3, Issue 10, p2290
- ISSN
1538-7933
- Publication type
Journal Article
- DOI
10.1111/j.1538-7836.2005.01479.x