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- Title
Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening.
- Authors
Soucie, J Michael; De Staercke, Christine; Monahan, Paul E; Recht, Michael; Chitlur, Meera B; Gruppo, Ralph; Hooper, W Craig; Kessler, Craig; Kulkarni, Roshni; Manco-Johnson, Marilyn J; Powell, Jerry; Pyle, Meredith; Riske, Brenda; Sabio, Hernan; Trimble, Sean; US Hemophilia Treatment Center Network
- Abstract
Parvovirus B19 (B19V) is a small, nonenveloped virus that typically causes a benign flu-like illness that occurs most frequently in childhood. The virus is resistant to current viral inactivation steps used in the manufacture of antihemophilic factor concentrates and B19V transmission through these products has been documented. Since 2000, B19V nucleic acid test (NAT) screening of plasma pools has been implemented to further decrease the viral burden in these products, but no study has examined populations using these products to assess the impact of the screening on B19V transmission.
- Publication
Transfusion, 2013, Vol 53, Issue 6, p1217
- ISSN
1537-2995
- Publication type
Journal Article
- DOI
10.1111/j.1537-2995.2012.03907.x