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- Title
Establishing assay cutoffs for HLA antibody screening of apheresis donors.
- Authors
Carrick, Danielle M; Norris, Philip J; Endres, Robert O; Pandey, Suchitra; Kleinman, Steven H; Wright, David; Sun, Yu; Busch, Michael P; National Heart, Lung, and Blood Institute Retrovirus Epidemiology Donor Study-II
- Abstract
Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related deaths. Donor HLA antibodies have been implicated in TRALI cases. Blood centers are implementing TRALI risk reduction strategies based on HLA antibody screening of some subpopulations of ever-pregnant apheresis platelet (PLT) donors. However, if screening assay cutoffs are too sensitive, donation loss may adversely impact blood availability.
- Publication
Transfusion, 2011, Vol 51, Issue 10, p2092
- ISSN
1537-2995
- Publication type
Journal Article
- DOI
10.1111/j.1537-2995.2010.03048.x