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- Title
Underestimation of the expression of cellular prion protein on human red blood cells.
- Authors
Panigaj, Martin; Brouckova, Adela; Glierova, Hana; Dvorakova, Eva; Simak, Jan; Vostal, Jaroslav G; Holada, Karel
- Abstract
Recent transmissions of variant Creutzfeldt-Jakob disease by blood transfusion emphasize the need for the development of prion screening tests. The detection of prions in blood is complicated by the presence of poorly characterized cellular prion protein (PrP(C) ) in both plasma and blood cells. According to published studies, most of PrP(C) in blood cells resides in platelets (PLTs) and white blood cells.
- Publication
Transfusion, 2011, Vol 51, Issue 5, p1012
- ISSN
1537-2995
- Publication type
Journal Article
- DOI
10.1111/j.1537-2995.2010.02924.x