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- Title
In vivo recovery of human platelets in severe combined immunodeficient mice as a measure of platelet damage.
- Authors
Piper, John T; Gelderman, Monique P; Vostal, Jaroslav G
- Abstract
Clinical performance of human platelet (PLT) products processed or stored under novel conditions is difficult to predict based on in vitro studies alone. Recovery and survival of radiolabeled PLTs in human subjects are used as surrogate markers for PLT efficacy in development of new products. Such experiments pose some risk to the participants, can be a financial burden on the sponsor, and may stifle innovation and development of new PLT products. Animal models for in vivo recovery and survival of human PLTs are limited by rapid, immune-mediated clearance of human cells. The severe combined immunodeficient (SCID) mice allowed prolonged circulation of human PLTs and were used to detect differences in recovery and survival between chemically damaged, aged PLTs, or normal PLTs.
- Publication
Transfusion, 2007, Vol 47, Issue 8, p1540
- ISSN
0041-1132
- Publication type
Journal Article
- DOI
10.1111/j.1537-2995.2007.01295.x