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- Title
Inactivation of parvovirus B19 in human platelet concentrates by treatment with amotosalen and ultraviolet A illumination.
- Authors
Sawyer, Lynette; Hanson, Deborah; Castro, Grace; Luckett, William; Dubensky, Thomas W, Jr; Stassinopoulos, Adonis
- Abstract
The human erythrovirus B19 (B19) is a small (18- to 26-nm) nonenveloped virus with a single-stranded DNA genome of 5.6 kb. B19 is clinically significant and is also generally resistant to pathogen inactivation methods. Photochemical treatment (PCT) with amotosalen and ultraviolet A (UVA) inactivates viruses, bacteria, and protozoa in platelets (PLTs) and plasma prepared for transfusion. In this study, the capacity of PCT to inactivate B19 in human PLT concentrates was evaluated.
- Publication
Transfusion, 2007, Vol 47, Issue 6, p1062
- ISSN
0041-1132
- Publication type
Journal Article
- DOI
10.1111/j.1537-2995.2007.01237.x