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- Title
Telomere length changes after umbilical cord blood transplant.
- Authors
Pipes, Brian L; Tsang, Tom; Peng, Shu-Xin; Fiederlein, Roger; Graham, Michael; Harris, David T
- Abstract
The establishment of donor-derived hematopoiesis in the recipients of hematopoietic stem cell (HSC) transplants involves extensive proliferation and differentiation of HSCs. Data from long-term survivors of HSC transplants suggest that these transplanted HSCs may experience a debilitating replicative senescence. A significant posttransplant shortening of peripheral blood mononuclear cell (PBMNC) telomeres has been observed in both marrow transplant and peripheral blood progenitor cell transplant recipients. Similar studies have not been performed for umbilical cord blood (UCB) HSC transplants, which might be expected to exhibit increased posttransplant replicative potential due to their inherently greater telomere length.
- Publication
Transfusion, 2006, Vol 46, Issue 6, p1038
- ISSN
0041-1132
- Publication type
Journal Article
- DOI
10.1111/j.1537-2995.2006.00839.x