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- Title
Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site.
- Authors
Debrouse, Lauren; Hurd, Benita; Kiselycznyk, Carly; Plitt, Aaron; Todaro, Alyssa; Mishina, Masayoshi; Grant, Seth G N; Camp, Marguerite; Gunduz-Cinar, Ozge; Holmes, Andrew
- Abstract
Stimulating the glycine(B) binding site on the N-methyl-d-aspartate ionotropic glutamate receptor (NMDAR) has been proposed as a novel mechanism for modulating behavioral effects of ethanol (EtOH) that are mediated via the NMDAR, including acute intoxication. Here, we pharmacologically interrogated this hypothesis in mice.
- Publication
Alcoholism, clinical and experimental research, 2013, Vol 37, Issue 2, p223
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2012.01922.x