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- Title
Chronic ethanol consumption alters all-trans-retinoic acid concentration and expression of their receptors on the prostate: a possible link between alcoholism and prostate damage.
- Authors
Fontanelli, Beatriz A F; Chuffa, Luiz G A; Teixeira, Giovana R; Amorim, João P A; Mendes, Leonardo O; Pinheiro, Patricia F F; Kurokawa, Cilmery S; Pereira, Sérgio; Fávaro, Wagner J; Martins, Otávio A; Mello Júnior, Wílson; Martinez, Marcelo; Júnior, Antonio Rugolo; Martinez, Francisco E
- Abstract
Ethanol (EtOH) alters the all-trans-retinoic acid (ATRA) levels in some tissues. Retinol and ATRA are essential for cell proliferation, differentiation, and maintenance of prostate homeostasis. It has been suggested that disturbances in retinol/ATRA concentration as well as in the expression of retinoic acid receptors (RARs) contribute to benign prostate hyperplasia and prostate cancer. This study aimed to evaluate whether EtOH consumption is able to alter retinol and ATRA levels in the plasma and prostate tissue as well as the expression of RARs, cell proliferation, and apoptosis index.
- Publication
Alcoholism, clinical and experimental research, 2013, Vol 37, Issue 1, p49
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2012.01866.x