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- Title
Naltrexone modification of drinking effects in a subacute treatment and bar-lab paradigm: influence of OPRM1 and dopamine transporter (SLC6A3) genes.
- Authors
Anton, Raymond F; Voronin, Konstantin K; Randall, Patrick K; Myrick, Hugh; Tiffany, Abraham
- Abstract
Naltrexone is moderately effective for the treatment of alcohol dependence, but there is great individual variability. The opioid receptor (OPRM1) single nucleotide polymorphism (SNP) asn40asp has been shown to alter alcohol and naltrexone response in animals and humans. In addition, the brain opioid and dopamine systems interact and might underlie drinking and craving. This study investigated the effects of the OPRM1 SNP and dopamine transporter (DAT) variable number of tandem repeat (VNTR) genetic differences on drinking, alcohol effects, and naltrexone response under controlled conditions in nontreatment-seeking alcoholics.
- Publication
Alcoholism, clinical and experimental research, 2012, Vol 36, Issue 11, p2000
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2012.01807.x