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- Title
Pilot study of iPS-derived neural cells to examine biologic effects of alcohol on human neurons in vitro.
- Authors
Lieberman, Richard; Levine, Eric S; Kranzler, Henry R; Abreu, Christine; Covault, Jonathan
- Abstract
Studies of the effects of alcohol on N-methyl-d-aspartate (NMDA) receptor function and gene expression have depended on rodent or postmortem human brain models. Ideally, the effects of alcohol might better be examined in living neural tissue derived from human subjects. In this study, we used new technologies to reprogram human subject-specific tissue into pluripotent cell colonies and generate human neural cultures as a model system to examine the molecular actions of alcohol.
- Publication
Alcoholism, clinical and experimental research, 2012, Vol 36, Issue 10, p1678
- ISSN
1530-0277
- Publication type
Journal Article
- DOI
10.1111/j.1530-0277.2012.01792.x